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However, one in vitro study in 2007 and later an in vivo study in 2008 have shown that tamoxifen induces apoptosis in growth plate chondrocytes, reduces serum igf-i levels and causes persistent retardation of longitudinal and cortical radial bone growth in young male rats, leading the researches to express concern giving tamoxifen to growing individuals.

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tamoxifen, however, can lead to a number of side effects, and cancers treated with tamoxifen can eventually become resistant to the drug.

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the point of tamoxifen is to prevent a recurrence of estrogen-receptive breast cancer.

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tamoxifen is most commonly used to treat breast cancer in women or men.
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